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J Pediatr Orthop：ADHA药物会降低骨密度？

2016-03-28 Seven L MedSci原创

ADHA骨密度儿童
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近期发表在J Pediatr Orthop的研究表明，服用与注意缺陷多动障碍症（ADHD）相关处方药物的儿童和青少年，其总股骨、股骨颈和腰椎的骨密度（BMD）降低。该研究纳入了5135名8-17岁的参与者，根据自我报告或监护人的报告处获取参与者处方药物的服用情况，根据药物使用情况将其分为药物使用足和非药物使用者，其中药物使用者包括ADHD相关药物和其他药物。此外，通过双能X线扫描获取参与者BMD情

近期发表在J Pediatr Orthop的研究表明，服用与注意缺陷多动障碍症（ADHD）相关处方药物的儿童和青少年，其总股骨、股骨颈和腰椎的骨密度（BMD）降低。

该研究纳入了5135名8-17岁的参与者，根据自我报告或监护人的报告处获取参与者处方药物的服用情况，根据药物使用情况将其分为药物使用足和非药物使用者，其中药物使用者包括ADHD相关药物和其他药物。此外，通过双能X线扫描获取参与者BMD情况。

研究数据显示，ADHD药物组与非药物组相比，总股骨和股骨颈BMD分别相差 -0.4855和-0.4671；对于腰椎，该值为-0.3947。此外，ADHD组和非药物组相比，BMD在骨质疏松症范围内的比例分别为38.3%和21.6%，两组间差异具有统计学意义。

研究者指出，因为ADHD相关药物可能具有潜在的骨健康风险，因此在使用时，医生和家长应该充分认识到这一风险。

原始出处：

Howard JT, et al. Preliminary Evidence of an Association Between ADHD Medications and Diminished Bone Health in Children and Adolescents.J Pediatr Orthop. 2016;doi:10.1097/BPO.0000000000000651.

Study links ADHD medication with lower BMD in children and adolescents.Healio.March 23, 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1726062, encodeId=9a231e26062ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 31 00:13:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637302, encodeId=acc4163e302d3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Nov 10 19:13:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74390, encodeId=fe83e43904f, content=这好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74391, encodeId=8a76e4391f0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-08-31 feather89

    #PE#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1726062, encodeId=9a231e26062ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 31 00:13:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637302, encodeId=acc4163e302d3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Nov 10 19:13:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74390, encodeId=fe83e43904f, content=这好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74391, encodeId=8a76e4391f0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-11-10 ms9608593228839890

    #DIA#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1726062, encodeId=9a231e26062ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Aug 31 00:13:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637302, encodeId=acc4163e302d3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Nov 10 19:13:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74390, encodeId=fe83e43904f, content=这好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74391, encodeId=8a76e4391f0, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Tue Mar 29 06:52:00 CST 2016, time=2016-03-29, status=1, ipAttribution=)]
    2016-03-29 milkshark

    这好文章

    0

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    2016-03-29 milkshark

    好好学习

    0