NEJM:新冠患者ST段抬高,应警惕冠脉非阻塞性疾病!新英格兰医学杂志研究

2020-04-21 xujing 中国循环杂志

新英格兰医学杂志的一篇通讯文章介绍了纽约6家医院的18例出现ST段抬高提示潜在心肌损伤的新冠病毒感染患者。

新英格兰医学杂志的一篇通讯文章介绍了纽约6家医院的18例出现ST段抬高提示潜在心肌损伤的新冠病毒感染患者。

研究者分析,这些有ST段抬高的新冠病毒感染患者中,表现有变异性,非阻塞性疾病发生率高,预后差。

该报告的18例患者中有一半的患者接受冠状动脉造影,其中2/3有冠脉阻塞病变。值得注意的是,所有18例患者的D-二聚体水平均升高。

18例患者的中位年龄为63岁,83%为男性,33%在ST段抬高时有胸痛。

共有10例(56%)患者在就诊时出现ST段抬高,另外8例患者在住院期间(中位数6天)出现ST段抬高。

14例(78%)ST段抬高患者中,5例(36%)左心室射血分数正常,其中1例(20%)出现局部室壁运动异常;8例(57%)左心室射血分数降低,其中5例(62%)出现局部室壁运动异常。

在4例弥漫性ST段抬高患者中,3例左室射血分数和室壁运动正常,1例患者左室射血分数为10%,整体运动减弱。

共有9例患者(50%)接受了冠状动脉造影;其中6例患者存在冠脉狭窄,5例患者接受了经皮冠状动脉介入治疗(1例患者药物溶栓治疗)。

临床诊断为心肌梗死的8例患者的肌钙蛋白和D-二聚体水平高于非冠状动脉心肌损伤的10例患者。

死亡13例(72%),其中心肌梗死4例,非冠状动脉心肌损伤9例。

研究者分析,新冠病毒感染患者的心肌损伤可能由斑块破裂、细胞因子风暴、缺氧损伤、冠状动脉痉挛、微血栓或直接内皮或血管损伤引起,这些患者的磁共振成像显示心肌间质水肿。

原始出处:
Bangalore S, et al. ST-segment elevation in patients with Covid-19 -- a case series. N Engl J Med 2020; DOI: 10.1056/NEJMc2009020.

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    2021-03-20 tomyang96
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topicList=[TopicDto(id=58057, encryptionId=317e5805e9d, topicName=新冠患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3e9205, createdName=tidiq, createdTime=Tue Mar 09 06:20:17 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423106, encodeId=7e301423106e4, content=<a href='/topic/show?id=936c16863b5' target=_blank style='color:#2F92EE;'>#ST段抬高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16863, encryptionId=936c16863b5, topicName=ST段抬高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=91d33758978, createdName=gdsun, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480134, encodeId=24f6148013456, content=<a href='/topic/show?id=311b58614a5' target=_blank style='color:#2F92EE;'>#新英格兰医学杂志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58614, encryptionId=311b58614a5, topicName=新英格兰医学杂志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fec7610558, createdName=ms9476844295372110, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624434, encodeId=2b401624434dd, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382058, encodeId=324c38205849, content=心肌间质的水肿,推测最有可能的是内皮损伤和炎症因子造成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=444b1718665, createdName=QQ047a06da, createdTime=Wed Apr 22 10:16:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027841, encodeId=121e102e841b7, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035239, encodeId=1c54103523973, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2025404, encodeId=5d60202540485, content=<a href='/topic/show?id=5d2a3101862' target=_blank style='color:#2F92EE;'>#冠脉非阻塞性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31018, encryptionId=5d2a3101862, topicName=冠脉非阻塞性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Mon Oct 19 15:20:17 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748693, encodeId=a3f01e486935e, content=<a href='/topic/show?id=52d15861349' target=_blank style='color:#2F92EE;'>#新英格兰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58613, encryptionId=52d15861349, topicName=新英格兰)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58614, encryptionId=311b58614a5, topicName=新英格兰医学杂志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fec7610558, createdName=ms9476844295372110, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624434, encodeId=2b401624434dd, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382058, encodeId=324c38205849, content=心肌间质的水肿,推测最有可能的是内皮损伤和炎症因子造成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=444b1718665, createdName=QQ047a06da, createdTime=Wed Apr 22 10:16:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027841, encodeId=121e102e841b7, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035239, encodeId=1c54103523973, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2025404, encodeId=5d60202540485, content=<a href='/topic/show?id=5d2a3101862' target=_blank style='color:#2F92EE;'>#冠脉非阻塞性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31018, encryptionId=5d2a3101862, topicName=冠脉非阻塞性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Mon Oct 19 15:20:17 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748693, encodeId=a3f01e486935e, content=<a href='/topic/show?id=52d15861349' target=_blank style='color:#2F92EE;'>#新英格兰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58613, encryptionId=52d15861349, topicName=新英格兰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3e36178621, createdName=shalley78, createdTime=Fri Mar 19 00:20:17 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696941, encodeId=8e5d16969414b, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sat Mar 20 10:20:17 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906512, encodeId=d368190651223, content=<a href='/topic/show?id=317e5805e9d' target=_blank style='color:#2F92EE;'>#新冠患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58614, encryptionId=311b58614a5, topicName=新英格兰医学杂志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fec7610558, createdName=ms9476844295372110, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624434, encodeId=2b401624434dd, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382058, encodeId=324c38205849, content=心肌间质的水肿,推测最有可能的是内皮损伤和炎症因子造成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=444b1718665, createdName=QQ047a06da, createdTime=Wed Apr 22 10:16:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027841, encodeId=121e102e841b7, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035239, encodeId=1c54103523973, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2025404, encodeId=5d60202540485, content=<a href='/topic/show?id=5d2a3101862' target=_blank style='color:#2F92EE;'>#冠脉非阻塞性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31018, encryptionId=5d2a3101862, topicName=冠脉非阻塞性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Mon Oct 19 15:20:17 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748693, encodeId=a3f01e486935e, content=<a href='/topic/show?id=52d15861349' target=_blank style='color:#2F92EE;'>#新英格兰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58613, encryptionId=52d15861349, topicName=新英格兰)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=58057, encryptionId=317e5805e9d, topicName=新冠患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3e9205, createdName=tidiq, createdTime=Tue Mar 09 06:20:17 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423106, encodeId=7e301423106e4, content=<a href='/topic/show?id=936c16863b5' target=_blank style='color:#2F92EE;'>#ST段抬高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16863, encryptionId=936c16863b5, topicName=ST段抬高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=91d33758978, createdName=gdsun, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480134, encodeId=24f6148013456, content=<a href='/topic/show?id=311b58614a5' target=_blank style='color:#2F92EE;'>#新英格兰医学杂志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58614, encryptionId=311b58614a5, topicName=新英格兰医学杂志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fec7610558, createdName=ms9476844295372110, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624434, encodeId=2b401624434dd, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Thu Apr 23 12:20:17 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382058, encodeId=324c38205849, content=心肌间质的水肿,推测最有可能的是内皮损伤和炎症因子造成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=444b1718665, createdName=QQ047a06da, createdTime=Wed Apr 22 10:16:33 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027841, encodeId=121e102e841b7, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035239, encodeId=1c54103523973, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
    2020-04-23 hyf035
  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
    2020-04-22 QQ047a06da

    心肌间质的水肿,推测最有可能的是内皮损伤和炎症因子造成。

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Apr 22 00:20:17 CST 2020, time=2020-04-22, status=1, ipAttribution=)]
    2020-04-22 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  10. 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    2020-04-22 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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