J Clin Med:铜和聚醚醚酮与钛相比,哪个更适合做种植体?

2020-05-08 MedSci原创 MedSci原创

骨整合可能是由免疫学驱动的骨骼对钛等材料产生免疫反应的结果。骨整合为口腔植入物锚固在颌骨组织中提供了临床可能性。然而,对骨固定背后的机制尚未完全了解,并且已报道了较长时期的并发症。本研究旨在探索不会发

骨整合可能是由免疫学驱动的骨骼对钛等材料产生免疫反应的结果。骨整合为口腔植入物锚固在颌骨组织中提供了临床可能性。然而,对骨固定背后的机制尚未完全了解,并且已报道了较长时期的并发症。本研究旨在探索不会发生骨整合的铜(Cu)和聚醚醚酮(PEEK)材料之间的可能差异,以骨整合cp钛为对照。

 

将植入物植入在兔胫骨中,并在随访的10天和28天评估选定的免疫标记物。Cu和PEEK在两个时间点均显示出比cp钛更高的免疫活性。由于持续的促炎环境,Cu表现出远距离成骨作用,而PEEK由于其表面上的免疫学定义的优先脂肪组织形成而无法形成骨整合。

 

总之,该研究结果揭示了两种不同的骨整合失败机制,这两种机制均与免疫系统相关。

 

原始出处:

 

Ricardo Trindade, Tomas Albrektsson, et al., Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia. J Clin Med. 2019 Jun 7;8(6):814. doi: 10.3390/jcm8060814.

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    2021-01-22 30397613

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    2020-05-14 huangdf

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    2020-05-10 ms6279672939590805

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    2020-05-10 智慧医人

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