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Nature Medicine：成纤维细胞生长因子19调节骨骼肌质量和改善肌肉萎缩！

2017-06-27 xing.T MedSci原创

FGF19骨骼肌萎缩
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总之，这些研究结果提供的证据表明FGF19是骨骼肌质量调节中的一种新因子，以及它对肌肉萎缩具有治疗的潜力。

内分泌来源的激素成纤维细胞生长因子（FGF）19是最近新出现的一个治疗代谢疾病的潜在靶点。由于骨骼肌是一个重要的代谢器官，研究人员重点探讨了FGF19在这类组织中的作用。近日，权威杂志Nature Medicine上发表了一篇研究文章，在这个研究中，研究人员报告了FGF19通过使肌纤维大小增大来调节骨骼肌质量的一个新功能，并防止肌肉萎缩。研究人员发现采用FGF19治疗会导致小鼠骨骼肌肥大，而生理和药理剂量的FGF19可以大幅地增加体外肌管的大小。而一个密切相关的内分泌FGF成员-FGF21并没有引起这些效应。无论是在体外和体内研究中，FGF19均可刺激细胞外信号调节蛋白激酶1/2（ERK1/2）和核糖体蛋白S6激酶（S6K1）的磷酸化，S6K1是一个调节肌细胞生长的mTOR依赖掌控调节因子。此外，骨骼肌特异性β-Klotho（KLB）基因缺陷的小鼠，对FGF19的肥大效应反应迟钝。最后，在小鼠中，FGF19可以改善肾上腺糖皮质激素治疗或肥胖以及少肌症引起的骨骼肌萎缩。总之，这些研究结果提供的证据表明FGF19是骨骼肌质量调节中的一种新因子，以及它对肌肉萎缩具有治疗的潜力。原始出处：Bé

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    2017-12-31 kalseyzl

    #CIN#

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    2017-12-05 chendoc252

    #萎缩#

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    2017-08-31 jeanqiuqiu

    #DIC#

    0

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createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-09-25 liye789132251

    #Nat#

    0

  5. 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createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 zhishijing

    #成纤维细胞#

    0

  6. 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encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 ms1065684921169360

    #骨骼肌#

    0

  7. 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topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 25 22:17:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307052, encodeId=a5ce130e0529f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333058, encodeId=1cbe133305832, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, 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createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 marongnuan

    #纤维细胞#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1773633, encodeId=adb21e73633e5, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Dec 31 20:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695804, encodeId=9c7116958040a, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Tue Dec 05 08:17:00 CST 2017, time=2017-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858761, encodeId=87181858e61b0, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Thu Aug 31 21:17:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882221, encodeId=a5061882221a7, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, 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createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 12499e01m50暂无昵称

    #生长因子#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1773633, encodeId=adb21e73633e5, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Dec 31 20:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695804, encodeId=9c7116958040a, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 25 22:17:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307052, encodeId=a5ce130e0529f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333058, encodeId=1cbe133305832, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, 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createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 wwzzly

    #细胞生长#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1773633, encodeId=adb21e73633e5, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Sun Dec 31 20:17:00 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695804, encodeId=9c7116958040a, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 25 22:17:00 CST 2017, time=2017-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307052, encodeId=a5ce130e0529f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333058, encodeId=1cbe133305832, content=<a href='/topic/show?id=4339101926f4' target=_blank style='color:#2F92EE;'>#骨骼肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101926, encryptionId=4339101926f4, topicName=骨骼肌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuNQXObUwZmFG3VcZa2uhFq27sY7vfTowUhQCgRj2bj1odUibMF4sFXpuRLf6IE5t5yGVDSiaOoOcQ/132, createdBy=1e622500088, createdName=ms1065684921169360, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462734, encodeId=20b01462e34c9, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517964, encodeId=d1f3151e96423, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569006, encodeId=6cda1569006c1, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577540, encodeId=bcff15e75402d, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jun 28 23:17:00 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 ms1692212821629096

    #Medicine#

    0

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