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CLIN CANCER RES：循环DNA表明结直肠治疗过程中出现趋同演化并揭示其抵抗机制

2017-08-23 MedSci MedSci原创

结直肠癌循环DNA趋同演化
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液体活检可以追踪克隆动力学并检测治疗过程中的突变情况。CLIN CANCER RES近期发表了一篇文章， 研究结直肠癌治疗过程中的基因突变情况。

液体活检可以追踪克隆动力学并检测治疗过程中的突变情况。CLIN CANCER RES近期发表了一篇文章， 研究结直肠癌治疗过程中的基因突变情况。

研究共纳入42例转移性结直肠癌患者。作者评估了盲法情况下游离DNA（cfDNA）检测患者血清RAS/BRAF突变的能力。所有患者接受FOLFOX和dasatinib治疗，联合或不联合西妥昔单抗。在治疗前，对患者保存的肿瘤组织的检测发现25例患者存在突变，而cfDNA检测到37例患者存在突变。cfDNA检测的等位基因突变频率低到0.01%。治疗后，41例患者出现了cfDNA检测到的RAS/BRAF突变。基线便存在RAS/BRAF突变的21例患者进行后续检测发现，11例患者在治疗过程中出现额外的点突变，3例患者未出现可检测到的其他等位突变。在基线为RAS/BRAF野生型的肿瘤患者中，80%的患者出现新的点突变。该研究中的cfDNA定量检测结果在CEA和CT结果变化中同样有所反应，表明收集特定点突变以外的其他定量数据的重要性。

文章最后认为，该研究表明患者无论是否之前存在突变，治疗过程中会出现新的RAS/BRAF突变，并呈现出趋同演化的模式。

原始出处：
Alain R.Thierry,Brice Pastor,et al.Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer.CLIN CANCER RES.August 2017 doi:10.1158/1078-0432.CCR-170232

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2018-02-22 xxxx1049

    #循环DNA#

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    2017-08-25 crystal0564

    #结直肠#

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    2017-08-24 龙胆草

    学习谢谢分享

    0

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    2017-08-24 135****7952平儿

    学了..........

    0

  5. 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    2017-08-24 luominglian113

    学习了.谢谢分享

    0

  6. 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    2017-08-23 有备才能无患

    该研究表明患者无论是否之前存在突变.治疗过程中会出现新的RAS/BRAF突变.并呈现出趋同演化的模式.

    0

  7. 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    2017-08-23 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  8. 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    2017-08-23 1de9c4fdm02(暂无匿称)

    学分了.

    0

  9. 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    2017-08-23 楠博One

    学习谢谢分享

    0

  10. 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    2017-08-23 ylzr123

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

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