Sci Rep:粘蛋白5B或是导致口腔扁平苔藓患者口干的原因

2017-10-14 MedSci MedSci原创

口腔扁平苔藓(OLP)是最常见的口腔疾病之一,目前其发病机制尚未明确。OLP患者常抱怨口干。本研究旨在评估伴有口干的OLP患者粘连蛋白5B的水平。研究人员选取了30例OLP患者和30例健康人进行研究。除了患者自述口干外,还通过压舌板和口红测试来评估。使用塑料瓶通过吐痰法收集经刺激和未刺激的唾液。通过ELISA检测粘蛋白5B的水平。OLP患者未刺激唾液流量明显降低(P = 0.0001)。两组间刺激

口腔扁平苔藓(OLP)是最常见的口腔疾病之一,目前其发病机制尚未明确。OLP患者常抱怨口干。本研究旨在评估伴有口干的OLP患者粘连蛋白5B的水平。

研究人员选取了30例OLP患者和30例健康人进行研究。除了患者自述口干外,还通过压舌板和口红测试来评估。使用塑料瓶通过吐痰法收集经刺激和未刺激的唾液。通过ELISA检测粘蛋白5B的水平。OLP患者未刺激唾液流量明显降低(P = 0.0001)。两组间刺激唾液流量差异无统计学意义(P> 0.05)。OLP组未刺激唾液中粘蛋白5B水平明显降低(P = 0。0001),而两组间刺激唾液差异无统计学意义(P> 0.05)。OLP患者血清中粘蛋白5B的水平升高(P = 0.016)。OLP患者的唾液流量和粘蛋白5B的水平均降低。

总之,该研究结果表明,由于粘蛋白5B对口腔润湿和润滑有效,所以这是OLP患者口干的可能原因。

原始出处:

Farzaneh Agha-Hosseini, Mojtaba Imanpour, et al., Mucin 5B in saliva and serum of patients with oral lichen planus. Sci Rep. 2017; 7: 12060. Published online 2017 Sep 21. doi:  10.1038/s41598-017-12157-1

评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1582193, encodeId=7d131582193af, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623169, encodeId=d4431623169e4, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253232, encodeId=cc37253232df, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Oct 15 22:58:15 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252920, encodeId=a31725292050, content=结论不能令人信服.也许口干所以这个蛋白表达异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Oct 14 22:19:06 CST 2017, time=2017-10-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1582193, encodeId=7d131582193af, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623169, encodeId=d4431623169e4, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253232, encodeId=cc37253232df, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Oct 15 22:58:15 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252920, encodeId=a31725292050, content=结论不能令人信服.也许口干所以这个蛋白表达异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Oct 14 22:19:06 CST 2017, time=2017-10-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1582193, encodeId=7d131582193af, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623169, encodeId=d4431623169e4, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253232, encodeId=cc37253232df, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Oct 15 22:58:15 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252920, encodeId=a31725292050, content=结论不能令人信服.也许口干所以这个蛋白表达异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Oct 14 22:19:06 CST 2017, time=2017-10-14, status=1, ipAttribution=)]
    2017-10-15 131****2916

    不错的文章值得推荐

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1582193, encodeId=7d131582193af, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623169, encodeId=d4431623169e4, content=<a href='/topic/show?id=805a5429014' target=_blank style='color:#2F92EE;'>#扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54290, encryptionId=805a5429014, topicName=扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95a320510292, createdName=whlxd, createdTime=Mon Oct 16 12:11:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253232, encodeId=cc37253232df, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Oct 15 22:58:15 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252920, encodeId=a31725292050, content=结论不能令人信服.也许口干所以这个蛋白表达异常, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Oct 14 22:19:06 CST 2017, time=2017-10-14, status=1, ipAttribution=)]
    2017-10-14 lovetcm

    结论不能令人信服.也许口干所以这个蛋白表达异常

    0

相关资讯

J Transl Med:口腔扁平苔藓患者HCMV编码miRNA表达模式明显不同

口腔扁平苔藓(OLP)是T细胞介导的免疫性疾病。口腔扁平苔藓的病因及分子机制目前仍不清楚。人巨细胞病毒(HCMV)感染是多种疾病发展的一个因素,但是HCMV在 OLP的临床相关性上目前还并不了解。研究共纳入了21名OLP患者和18名健康对照者,收集器血浆样本,使用RT-qPCR 检查了23个HCMV编码的microRNA(miRNA)。随后在包括40例OLP患者和33名健康对照者的更大队列中验证了