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Nature：HIV/AIDS疫苗存在的问题

2014-01-26 Natureasia Natureasia

HIV/AIDS疫苗

“人免疫缺陷病毒-1”(HIV-1)疫苗的临床试验迄今为止是令人失望的，不是疗效低就是没疗效（零保护）。 在这篇论文中，Mario Roederer等人分析了多疫苗方案在“猴免疫缺陷病毒”(SIV)的恒河猴模型中的效果，发现了一个关键的“二氨基酸”特征，它使病毒对中和抗体产生抵抗力。 免疫逃避的一个类似机制被发现在HIV中也起作用，说明这种类型的由疫苗引发的抗体反应也许可解释为什么在HIV疫苗

“人免疫缺陷病毒-1”(HIV-1)疫苗的临床试验迄今为止是令人失望的，不是疗效低就是没疗效（零保护）。【原文下载】

在这篇论文中，Mario Roederer等人分析了多疫苗方案在“猴免疫缺陷病毒”(SIV)的恒河猴模型中的效果，发现了一个关键的“二氨基酸”特征，它使病毒对中和抗体产生抵抗力。

免疫逃避的一个类似机制被发现在HIV中也起作用，说明这种类型的由疫苗引发的抗体反应也许可解释为什么在HIV疫苗试验中疗效有限。

原文出处

Roederer M1, Keele BF2, Schmidt SD1, Mason RD1, Welles HC3, Fischer W4, Labranche C5, Foulds KE1, Louder MK1, Yang ZY6, Todd JP1, Buzby AP7, Mach LV7, Shen L7, Seaton KE8, Ward BM5, Bailer RT1, Gottardo R9, Gu W10, Ferrari G5, Alam SM8, Denny TN8, Montefiori DC5, Tomaras GD8, Korber BT4, Nason MC10, Seder RA1, Koup RA1, Letvin NL11, Rao SS1, Nabel GJ6, Mascola JR1.Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Nature. 2014 Jan 23【原文下载】

评论区 (4)
#插入话题
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    2014-03-21 xuyu

    #HIV/AIDS#

    0

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    2014-08-21 liye789132251

    #Nat#

    0

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    2014-09-21 wjywjy

    #AID#

    0

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    2014-01-28 cooco

    #AIDS#

    0