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Ann Med：福建省立医院朱鹏立发现Apelin或是潜在的降压治疗靶点

2013-12-27 desperado-c dxy

Apelin降压
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研究要点：1.该研究探讨中国沿海居民血浆apelin水平与血压的关系；2.发现收缩压、舒张压和平均动脉血压与apelin水平呈显著负相关。为了描述中国沿海居民血浆apelin水平与血压的关系，来自中国福建医科大学附属福建省立医院老年科朱鹏立教授及其团队进行了一项研究，该研究发现中国沿海居民血浆apelin水平与血压呈负相关。该研究结果发表在2013年11月的Annals of medicine杂志

研究要点：1.该研究探讨中国沿海居民血浆apelin水平与血压的关系；2.发现收缩压、舒张压和平均动脉血压与apelin水平呈显著负相关。为了描述中国沿海居民血浆apelin水平与血压的关系，来自中国福建医科大学附属福建省立医院老年科朱鹏立教授及其团队进行了一项研究，该研究发现中国沿海居民血浆apelin水平与血压呈负相关。该研究结果发表在2013年11月的Annals of medicine杂志上，该杂志影响因子为5.094。该研究是一项横断面研究，在中国沿海地区共招募了1031例受试者。使用单因素方差分析（ANOVA）、线性趋势检验、 Pearson相关分析、以及多元线性回归分析评估血浆apelin水平与血压之间的关系。【原文下载】该研究结果表明，随着收缩压（SBP）、舒张压（DBP）和平均动脉血压（MABP）的四分位数增加，血浆apelin水平下降。随着apelin水平在四分位数内增加，SBP、DBP和MABP值下降。校正年龄和性别后，apelin四分位数不同组之间SBP、DBP和MABP仍有显著差异。该研究观察到SBP、DBP以及MABP与apelin水平呈显著负相关；即使在校

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    2014-09-03 qindq

    #Apelin#

    0

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    2014-11-29 feather89

    #PE#

    0

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    2014-02-05 ewsr9

    #福建省#

    0

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    2014-02-06 drj2003

    #治疗靶点#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2036581, encodeId=9424203658128, content=<a href='/topic/show?id=2dfd2634c7' target=_blank style='color:#2F92EE;'>#Apelin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2634, encryptionId=2dfd2634c7, topicName=Apelin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Wed Sep 03 11:43:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725562, encodeId=8b911e255629e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Nov 29 03:43:00 CST 2014, time=2014-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655064, encodeId=d57f16550645b, content=<a href='/topic/show?id=49d8e4680a4' target=_blank style='color:#2F92EE;'>#福建省#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74680, encryptionId=49d8e4680a4, topicName=福建省)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5b1b24623883, createdName=ewsr9, createdTime=Wed Feb 05 10:43:00 CST 2014, time=2014-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895305, encodeId=06f11895305de, content=<a href='/topic/show?id=18ae64e21d3' target=_blank style='color:#2F92EE;'>#治疗靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64721, encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Thu Feb 06 07:43:00 CST 2014, time=2014-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291808, encodeId=bc9b129180849, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360837, encodeId=e659136083eff, content=<a href='/topic/show?id=87fe98146d7' target=_blank style='color:#2F92EE;'>#降压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98146, encryptionId=87fe98146d7, topicName=降压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606077, encodeId=be4716060e77f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625819, encodeId=8c071625819be, content=<a href='/topic/show?id=bc29140196e' target=_blank style='color:#2F92EE;'>#PEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14019, encryptionId=bc29140196e, topicName=PEL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=399320916411, createdName=tidiq, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=)]
    2013-12-29 经常头晕

    #降压#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2036581, encodeId=9424203658128, content=<a href='/topic/show?id=2dfd2634c7' target=_blank style='color:#2F92EE;'>#Apelin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2634, encryptionId=2dfd2634c7, topicName=Apelin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Wed Sep 03 11:43:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725562, encodeId=8b911e255629e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Nov 29 03:43:00 CST 2014, time=2014-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655064, encodeId=d57f16550645b, content=<a href='/topic/show?id=49d8e4680a4' target=_blank style='color:#2F92EE;'>#福建省#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74680, encryptionId=49d8e4680a4, topicName=福建省)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5b1b24623883, createdName=ewsr9, createdTime=Wed Feb 05 10:43:00 CST 2014, time=2014-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895305, encodeId=06f11895305de, content=<a href='/topic/show?id=18ae64e21d3' target=_blank style='color:#2F92EE;'>#治疗靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64721, encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Thu Feb 06 07:43:00 CST 2014, time=2014-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291808, encodeId=bc9b129180849, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360837, encodeId=e659136083eff, content=<a href='/topic/show?id=87fe98146d7' target=_blank style='color:#2F92EE;'>#降压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98146, encryptionId=87fe98146d7, topicName=降压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606077, encodeId=be4716060e77f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625819, encodeId=8c071625819be, content=<a href='/topic/show?id=bc29140196e' target=_blank style='color:#2F92EE;'>#PEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14019, encryptionId=bc29140196e, topicName=PEL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=399320916411, createdName=tidiq, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=)]
    2013-12-29 xugumin

    #降压治疗#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2036581, encodeId=9424203658128, content=<a href='/topic/show?id=2dfd2634c7' target=_blank style='color:#2F92EE;'>#Apelin#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2634, encryptionId=2dfd2634c7, topicName=Apelin)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Wed Sep 03 11:43:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725562, encodeId=8b911e255629e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Nov 29 03:43:00 CST 2014, time=2014-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655064, encodeId=d57f16550645b, content=<a href='/topic/show?id=49d8e4680a4' target=_blank style='color:#2F92EE;'>#福建省#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74680, encryptionId=49d8e4680a4, topicName=福建省)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5b1b24623883, createdName=ewsr9, createdTime=Wed Feb 05 10:43:00 CST 2014, time=2014-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895305, encodeId=06f11895305de, content=<a href='/topic/show?id=18ae64e21d3' target=_blank style='color:#2F92EE;'>#治疗靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64721, encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Thu Feb 06 07:43:00 CST 2014, time=2014-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291808, encodeId=bc9b129180849, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360837, encodeId=e659136083eff, content=<a href='/topic/show?id=87fe98146d7' target=_blank style='color:#2F92EE;'>#降压治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98146, encryptionId=87fe98146d7, topicName=降压治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606077, encodeId=be4716060e77f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625819, encodeId=8c071625819be, content=<a href='/topic/show?id=bc29140196e' target=_blank style='color:#2F92EE;'>#PEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14019, encryptionId=bc29140196e, topicName=PEL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=399320916411, createdName=tidiq, createdTime=Sun Dec 29 01:43:00 CST 2013, time=2013-12-29, status=1, ipAttribution=)]
    2013-12-29 ms3994565386320060

    #Med#

    0

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    2013-12-29 tidiq

    #PEL#

    0