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Bavarian Nordic完成了Chordoma II期试验治疗脊索瘤的患者入组

2019-01-29 MedSci MedSci原创

Chordoma脊索瘤BN-Brachyury
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Bavarian Nordic近日宣布，已完成新型靶向癌症免疫治疗候选药物BN-Brachyury治疗晚期脊索瘤的II期临床研究第一阶段的患者入组。Chordoma II期旨在确定BN-Brachyury疫苗与目前的护理标准相结合时，是否能产生临床意义的客观反应率（ORR）。BN-Brachyury旨在引导T细胞攻击表达Brachyury的细胞并杀死肿瘤细胞。

Bavarian Nordic近日宣布，已完成新型靶向癌症免疫治疗候选药物BN-Brachyury治疗晚期脊索瘤的II期临床研究第一阶段的患者入组。Chordoma II期旨在确定BN-Brachyury疫苗与目前的护理标准相结合时，是否能产生临床意义的客观反应率（ORR）。BN-Brachyury旨在引导T细胞攻击表达Brachyury的细胞并杀死肿瘤细胞。

根据研究设计，前10名患者现已入组，从而完成了研究的第1阶段的招募。该阶段的第一批结果预计将在2019年下半年推出。Bavarian Nordic公司总裁兼首席执行官保罗·卓别林说：“我们对脊索瘤研究的结果感到兴奋。由于没有批准用于治疗脊索瘤的药物，患者在控制疾病的选择方面确实受到限制，特别是在晚期阶段。我们希望证明，有针对性的免疫疗法可以改善这些患者的预后并提供希望让癌症患者过上更好的生活”。脊索瘤起源于胚胎残留的脊索组织。在胚胎期间，脊索上端分布于颅底的蝶骨和枕骨，部分达到颅内面，并与蝶鞍上方的硬脑膜相衔接，在枕骨部分可达该骨之下面（即舌咽面），一部分亦可位于颅底骨和咽壁之间。


原始出处：

http://www.firstwordpharma.com/node/1620863#axzz5dfw0Z0Ih

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2019-11-17 jeanqiuqiu

    #DIC#

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    2019-09-26 ms5187542471278033

    #II期试验#

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    2019-12-27 qindq

    #脊索瘤#

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