Pulm Circ:肺动脉病变可能是PEA后RPE的发展和严重程度的决定因素

2020-04-04 MedSci原创 MedSci原创

再灌注性肺水肿(RPE)是慢性血栓栓栓塞性肺动脉内膜切除术(PEA)后的常见并发症。然而,RPE发生的确切机制仍不清楚。

再灌注性肺水肿(RPE)是慢性血栓栓栓塞性肺动脉内膜切除术(PEA)后的常见并发症。然而,RPE发生的确切机制仍不清楚。

 

为了评估肺血管病变对RPE的影响,我们对33例CTEPH患者进行了PEA时活检的肺动脉病变和肺组织静脉病变的严重程度进行了病理量化。根据动脉血氧张力/吸氧分压比(P/F比值)和呼吸管理的必要性,将RPE的严重程度从0级(无RPE)到4级(因RPE而死亡)。

 

在33名患者(27名女性;平均年龄=63.3岁)中,17名(51.5%)患者出现了RPE。肺动脉病变的严重程度(阻塞率)与RPE的等级相关(r=0.576,P=0.0005)。阻塞比也与P/F比(r =-0.543,P = 0.001)和围术期平均肺动脉压(r = 0.445,P = 0.009)相关。多变量logistic回归分析显示,梗阻率是RPE发生的一个显著的独立决定因素(概率=15.7;95%置信区间=2.29-108.00,P=0.005)。

 

总之,该研究结果表明,肺动脉病变可能是PEA后RPE的发展和严重程度的决定因素。

 

原始出处:

 

Takayuki Jujo SanadaNobuhiro Tanabe, et al., Involvement of pulmonary arteriopathy in the development and severity of reperfusion pulmonary edema after pulmonary endarterectomy. Pulm Circ. 2019 Apr-Jun; 9(2): 2045894019846439.

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