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Tissue Eng Part A：预处理或IL4-分泌间充质干细胞在不同阶段增强成骨作用

2019-01-26 MedSci MedSci原创

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慢性炎症相关骨病涉及持续破坏和骨再生受损。基于间充质干细胞（MSC）的疗法具有调节炎症反应和增强组织再生的巨大潜力。我们以前表明脂多糖[LPS]加TNFα预处理的MSCs或基因修饰的炎症感应（由NFB激活驱动）分泌IL4的MSCs增强了巨噬细胞对更理想的组织修复M2型的免疫调节作用。在目前的研究中，使用体外transwell系统检查治疗性MSC的旁分泌调节对促炎反应和巨噬细胞-MSC共培养物（代

慢性炎症相关骨病涉及持续破坏和骨再生受损。基于间充质干细胞（MSC）的疗法具有调节炎症反应和增强组织再生的巨大潜力。我们以前表明脂多糖[LPS]加TNFα预处理的MSCs或基因修饰的炎症感应（由NFB激活驱动）分泌IL4的MSCs增强了巨噬细胞对更理想的组织修复M2型的免疫调节作用。在目前的研究中，使用体外transwell系统检查治疗性MSC的旁分泌调节对促炎反应和巨噬细胞-MSC共培养物（代表内源细胞）的成骨作用。

在共培养物中，分泌IL4的MSC降低TNFα和iNOS表达，并且在LPS污染的聚乙烯颗粒存在下增加精氨酸酶1和CD206表达。在污染颗粒存在下，预处理的MSC降低底部MSC-巨噬细胞共培养物中的TNFα和CD206表达。在成骨测定中，分泌IL4的MSC降低ALP表达，但在污染颗粒存在下增加茜素红染色。预处理的MSCs增加ALP和骨钙素的表达，对茜素红染色无明显影响。

这些结果表明，在较早阶段使用预处理的MSC或在晚期使用分泌IL4的MSC的潜在治疗可以增强炎性病症（包括假体周围骨溶解）中的骨再生。

原始出处：

Lin TH, Kohno Y, et al., Preconditioned or IL4-Secreting Mesenchymal Stem Cells Enhanced Osteogenesis at Different Stages. Tissue Eng Part A. 2019 Jan 17. doi: 10.1089/ten.TEA.2018.0292.

评论区 (6)
#插入话题
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    2019-02-10 xuyu

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    2019-06-01 gwc392

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    2019-06-01 h.y200607_23674418

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    2019-02-28 spoonycyy

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    2019-01-27 zhaojie88

    #成骨#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1911372, encodeId=2ce119113e214, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Feb 10 07:35:00 CST 2019, time=2019-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682500, encodeId=f8a1168250011, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Jun 01 14:35:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815441, encodeId=6ef21815441fb, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Jun 01 16:35:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081524, encodeId=04b220815247c, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Thu Feb 28 09:35:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351978, encodeId=bb6d13519e888, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 17:35:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357088, encodeId=795a135e08898, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 27 17:35:00 CST 2019, time=2019-01-27, status=1, ipAttribution=)]
    2019-01-27 zhaojie88

    #ART#

    0