PLoS One:新型改性的二氧化硅材料可有效抗菌

2017-12-21 MedSci MedSci原创

本研究旨在使用(i)带有两个t-肉桂醛取代基的叔胺或(ii)二甲基辛基铵合成改性的二氧化硅纳米粒子,同时探究季铵聚乙烯亚胺纳米粒子。评估其化学和机械性能,以及抗菌和抗生物膜活性。将样品掺入商业牙科树脂材料中,测试单体转化度,机械强度和水接触角以表征纳米颗粒对树脂材料的影响。使用直接接触试验和对变形链球菌的生物膜抑制试验评价抗菌活性。肉桂醛改性颗粒的添加保持了基材的转化程度和抗压强度,并增加了表面疏

本研究旨在使用(i)带有两个t-肉桂醛取代基的叔胺或(ii)二甲基辛基铵合成改性的二氧化硅纳米粒子,同时探究季铵聚乙烯亚胺纳米粒子。评估其化学和机械性能,以及抗菌和抗生物膜活性。

将样品掺入商业牙科树脂材料中,测试单体转化度,机械强度和水接触角以表征纳米颗粒对树脂材料的影响。使用直接接触试验和对变形链球菌的生物膜抑制试验评价抗菌活性。肉桂醛改性颗粒的添加保持了基材的转化程度和抗压强度,并增加了表面疏水性。季铵官能团导致转化度降低并且抗压强度低,而不改变基材的亲水性。直接接触试验和抗生物膜试验中,聚乙烯亚胺颗粒表现出最强的抗菌效果。肉桂醛修饰颗粒表现出抗菌活性,而含季铵盐的二氧化硅颗粒无效。

综上所述,该研究结果表明,通过胺连接基团将t-肉桂醛固定到固体表面上提供了比季铵杀菌剂更好的替代方法。

原始出处:

Zaltsman N, Ionescu AC, et al., Surface-modified nanoparticles as anti-biofilm filler for dental polymers. PLoS One. 2017 Dec 15;12(12):e0189397. doi: 10.1371/journal.pone.0189397. eCollection 2017.

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    2017-12-22 hhh678

    henhao

    0

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    2017-12-22 139****0239

    henhao

    0

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    2017-12-22 明月清辉

    谢谢分享.学习了

    0

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    2017-12-22 飛歌

    学习了很有用

    0

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    2017-12-21 清风拂面

    谢谢.学习了.

    0

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    2017-12-21 131****2916

    不错的文章值得推荐

    0