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Biomaterials：钛上的多面涂层决定了骨免疫调节和骨/血管生成可改善骨整合

2018-03-15 MedSci MedSci原创

关注

用于植体的多层涂层具有良好的骨生成、血管生成和骨免疫调节能力，因为它可以改善骨整合并减轻植体松动，因此具有重要价值。但是，迄今为止，几乎没有完全符合这些标准的涂料。在此我们描述了用纯钛（Ti）的微弧氧化并随后退火产生的用羟基磷灰石（HA）纳米颗粒修饰的微孔TiO 2涂层。通过改变退火温度，可以同时调整涂层的物理（形态和润湿性）和化学（复合材料和结晶度）性质。采用退火温度为650℃的微弧氧化（MAO

用于植体的多层涂层具有良好的骨生成、血管生成和骨免疫调节能力，因为它可以改善骨整合并减轻植体松动，因此具有重要价值。但是，迄今为止，几乎没有完全符合这些标准的涂料。在此我们描述了用纯钛（Ti）的微弧氧化并随后退火产生的用羟基磷灰石（HA）纳米颗粒修饰的微孔TiO 2涂层。

通过改变退火温度，可以同时调整涂层的物理（形态和润湿性）和化学（复合材料和结晶度）性质。采用退火温度为650℃的微弧氧化（MAO）制成的涂层（MAO-650）显示出许多有利的物理化学性质，例如混合微纳米形态、超亲水性和高度结晶的HA纳米颗粒。体外实验表明，MAO-650涂层不仅支持成骨细胞和内皮细胞的增殖和分化，而且还抑制巨噬细胞的炎症反应，并使得有利的骨免疫调节促进骨/血管生成。体内评估反映了这些结果，且显示与原始MAO涂层相比，MAO-650涂层可改善骨整合。

综上所述，该研究结果表明，植体表面物理化学性质对调节骨/血管生成和骨增强骨整合中的骨免疫调节的深远影响。

原始出处：

Bai L, Du Z, et al., A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration. Biomaterials. 2018 Apr;162:154-169. doi: 10.1016/j.biomaterials.2018.02.010. Epub 2018 Feb 6.

评论区 (5)
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    2018-06-29 sunylz

    #Bio#

    0

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    2018-05-31 30397613

    #钛#

    0

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    2019-02-11 zhangyxzsh

    #Biomaterials#

    0

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    2018-03-17 bnurmamat

    #骨整合#

    0

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    2018-03-16 changjiu

    学习一下谢谢

    0