J Biomed Mater Res B Appl Biomater:干细胞复合水凝胶伤口敷料可促进伤口愈合和皮肤再生

2018-04-11 MedSci MedSci原创

在该研究中,研究人员使用小鼠和猪模型研究了明胶基水凝胶(GBH)伤口敷料联合脂肪源性干细胞(ADSC)在伤口愈合中的效果。 体外研究结果显示,与从小鼠获得的ADSCs相比,从猪获得的ADSCs可显著增加细胞生长并促进细胞分化(脂肪形成和骨生成)。 此外,体内结果也表明,GBH伤口敷料联合ADSCs及其培养基可以加速小鼠和猪模型中的伤口愈合。ADSCs提供了通过皮肤再生从伤口和损伤中恢复的可能性。

在该研究中,研究人员使用小鼠和猪模型研究了明胶基水凝胶(GBH)伤口敷料联合脂肪源性干细胞(ADSC)在伤口愈合中的效果。

体外研究结果显示,与从小鼠获得的ADSCs相比,从猪获得的ADSCs可显著增加细胞生长并促进细胞分化(脂肪形成和骨生成)。 此外,体内结果也表明,GBH伤口敷料联合ADSCs及其培养基可以加速小鼠和猪模型中的伤口愈合。ADSCs提供了通过皮肤再生从伤口和损伤中恢复的可能性。

因此,体外和体内结果都表明,ADSCs可能通过GBH伤口敷料进行有效的临床治疗,这是一种很有前景的用于皮肤再生的补充和替代药物。

原始出处:

Hsu LC, Peng BY, et al., The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation. J Biomed Mater Res B Appl Biomater. 2018 Mar 26. doi: 10.1002/jbm.b.34118.

评论区 (7)
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    2018-04-19 sunylz

    #Bio#

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    2018-07-03 guozhenyu

    #敷料#

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    2018-04-13 tastas

    #水凝胶#

    0

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    2018-04-13 chenzhuanggui
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    2018-04-13 lishizhe

    #凝胶#

    0

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    2018-04-13 ms3994565386320060

    #Med#

    0

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    2018-04-12 飛歌

    学习了很有用

    0