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Neuroradiology：利用多参数定量MRI定量评价儿童髓鞘的价值。

2017-09-07 shaosai MedSci原创

多参数定量MRI髓鞘化儿童
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髓鞘化是指髓鞘发展的过程，它使神经兴奋在沿神经纤维传导时速度加快，并保证其定向传导。是新生儿的神经系统发展必不可少的过程。本研究旨在评价多参数定量MRI对儿童髓鞘化定量的价值，并将结果发表在Neuroradiology上。

髓鞘化是指髓鞘发展的过程，它使神经兴奋在沿神经纤维传导时速度加快，并保证其定向传导。是新生儿的神经系统发展必不可少的过程。本研究旨在评价多参数定量MRI对儿童髓鞘化定量的价值，并将结果发表在Neuroradiology上。本研究共纳入了22名儿童，并行多参数定量MRI检查。测量髓鞘的总体积（Msum）、髓鞘占脑实质的百分比（Mbpv）、髓鞘体积占颅脑体积的百分比（Micv）。检查4种髓鞘成熟的发育模型（logarithmic模型、logistic模型、 Gompertz模型、改良Gompertz 模型）来找出3个参数最具有代表性的模型。在不同的脑区域测量髓鞘化的体积并评价模型的拟合优度。Msum、Mbpv和Micv的范围分别为0.8-160.9 ml、0.2-13%、0.0-11.6%。对于这3个参数，Gompertz模型是最好的。在每个脑区的髓鞘发育模型分析中，Gompertz模型是在脑桥（R 2 = 74.6%）、小脑中脚（R 2 = 76.4%）、壳核（R2 = 95.8%）和半卵圆中心（R 2 = 77.7%）的最佳模型。Logistic模型是在胼胝体的膝部和压部（R 2 =

评论区 (6)
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  1. [GetPortalCommentsPageByObjectIdResponse(id=2085355, encodeId=b9592085355b0, content=<a href='/topic/show?id=3fc2459e9ce' target=_blank style='color:#2F92EE;'>#定量MRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45979, encryptionId=3fc2459e9ce, topicName=定量MRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Mar 19 02:41:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755056, encodeId=68a91e550562c, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, createdName=xiaogang329, createdTime=Sun Dec 24 17:41:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242839, encodeId=5227242839c0, content=文章不错.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 11 10:58:15 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444259, encodeId=bfe91444259bf, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Sep 09 10:41:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242142, encodeId=1b62242142f1, content=认真学习.不断进步.把经验分享给同好.点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 09 10:26:24 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241696, encodeId=5bae24169698, content=好好学习.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Fri Sep 08 09:34:00 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2018-03-19 xuyong523

    #定量MRI#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2085355, encodeId=b9592085355b0, content=<a href='/topic/show?id=3fc2459e9ce' target=_blank style='color:#2F92EE;'>#定量MRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45979, encryptionId=3fc2459e9ce, topicName=定量MRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Mar 19 02:41:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755056, encodeId=68a91e550562c, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, createdName=xiaogang329, createdTime=Sun Dec 24 17:41:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242839, encodeId=5227242839c0, content=文章不错.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 11 10:58:15 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444259, encodeId=bfe91444259bf, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Sep 09 10:41:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242142, encodeId=1b62242142f1, content=认真学习.不断进步.把经验分享给同好.点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 09 10:26:24 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241696, encodeId=5bae24169698, content=好好学习.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Fri Sep 08 09:34:00 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-12-24 xiaogang329

    #髓鞘#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2085355, encodeId=b9592085355b0, content=<a href='/topic/show?id=3fc2459e9ce' target=_blank style='color:#2F92EE;'>#定量MRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45979, encryptionId=3fc2459e9ce, topicName=定量MRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Mar 19 02:41:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755056, encodeId=68a91e550562c, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, createdName=xiaogang329, createdTime=Sun Dec 24 17:41:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242839, encodeId=5227242839c0, content=文章不错.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 11 10:58:15 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444259, encodeId=bfe91444259bf, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Sep 09 10:41:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242142, encodeId=1b62242142f1, content=认真学习.不断进步.把经验分享给同好.点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 09 10:26:24 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241696, encodeId=5bae24169698, content=好好学习.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Fri Sep 08 09:34:00 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-11 1e10c84am36(暂无匿称)

    文章不错.值得分享

    0

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    2017-09-09 huagfeg

    #评价#

    0

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    2017-09-09 ylzr123

    认真学习.不断进步.把经验分享给同好.点赞了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2085355, encodeId=b9592085355b0, content=<a href='/topic/show?id=3fc2459e9ce' target=_blank style='color:#2F92EE;'>#定量MRI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45979, encryptionId=3fc2459e9ce, topicName=定量MRI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Mar 19 02:41:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755056, encodeId=68a91e550562c, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, createdName=xiaogang329, createdTime=Sun Dec 24 17:41:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242839, encodeId=5227242839c0, content=文章不错.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Sep 11 10:58:15 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444259, encodeId=bfe91444259bf, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Sat Sep 09 10:41:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=242142, encodeId=1b62242142f1, content=认真学习.不断进步.把经验分享给同好.点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Sep 09 10:26:24 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241696, encodeId=5bae24169698, content=好好学习.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Fri Sep 08 09:34:00 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 shaosai

    好好学习.涨知识

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