J Infect Dev Ctries:警惕重症监护病房中新生儿耐甲氧西林葡萄球菌感染

2020-02-20 不详 网络

葡萄球菌定植是与医疗保健相关的感染的危险因素,在新生儿重症监护病房(NICU)中很常见。这项研究分析了葡萄球菌属的微生物学,流行病学和临床方面。定居的新生儿。研究人员于2009年3月至2009年9月在里约热内卢一家医院的重症监护病房(NICU)收治的175名新生儿中评估了鼻拭子或脐周拭子。从医疗记录中获得临床数据。通过PCR检测SCCmec分型以及mecA和Panton-Valentine Leu

葡萄球菌定植是与医疗保健相关的感染的危险因素,在新生儿重症监护病房(NICU)中很常见。这项研究分析了葡萄球菌属的微生物学,流行病学和临床方面。定居的新生儿。

研究人员于2009年3月至2009年9月在里约热内卢一家医院的重症监护病房(NICU)收治的175名新生儿中评估了鼻拭子或脐周拭子。从医疗记录中获得临床数据。通过PCR检测SCCmec分型以及mecA和Panton-Valentine Leukocidin(PVL)基因。通过脉冲场凝胶电泳评估克隆多样性。

结果显示,金黄色葡萄球菌在98名(56%)新生儿中检出分离株,其中66.3%的出生体重≤2500 g,62.2%早产(˂37周),平均住院时间为14.9天。在鉴定出的133种分离物中,表皮葡萄球菌,溶血链球菌和金黄色葡萄球菌分别占48.1%,23.3%和13.5%。在77.6%的新生儿中检出了耐甲氧西林的葡萄球菌。耐甲氧西林的金黄色葡萄球菌带有IV型SCCmec,而表皮葡萄球菌和溶血链球菌的94.6%和溶血链球菌有85.7%属于不可分型盒。在金黄色葡萄球菌中,有55.6%具有PVL基因,并且USA800基因型是普遍的。表皮葡萄球菌的两种基因型和溶血链球菌的一种基因型分别聚集了分离株的42.2%和25.8%。溶血性沙门氏菌定植与使用肠外营养和机械通气有关。

综上所述,该研究结果表明,耐甲氧西林金黄色葡萄球菌种所定居的新生儿比例很高,并且新生儿重症监护病房(NICU)中流通的克隆的持久性凸显了对该高危人群进行连续和预防性监测的重要性。

原始出处:

Salgueiro VC, Seixas MDL, et al., High rate of neonates colonized by methicillin-resistant Staphylococcus species in an Intensive Care Unit. J Infect Dev Ctries. 2019 Sep 30;13(9):810-816. doi: 10.3855/jidc.11241.

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