Biosci Rep:肝细胞癌患者半肝切除术后肝再生和肝切除术后肝功能衰竭的评估

2020-03-18 MedSci原创 MedSci原创

本研究旨在探讨与半肝切除术治疗肝细胞癌(HCC)后肝脏再生程度相关的临床因素。

本研究旨在探讨与半肝切除术治疗肝细胞癌(HCC)后肝脏再生程度相关的临床因素。

 

术前以及术后1、5、9和13周测量未来肝残余量(以功能肝体积的百分比,%FLRV)和肝残余量。

 

结果显示,肝切除术后,125例患者中有1例(0.8%)在3个月内死亡,13例(10.4%)经历了肝衰竭,99例(79.2%)经历了并发症。%FLRV能够预测肝功能衰竭,受试者工作特征曲线下的面积为0.900,临界值42.7%显示灵敏度为85.7%,特异性为88.6%。术后1周的中位生长率为21.3%,5周为30.9%,9周为34.6%,13周为37.1%。多变量分析确定了与肝再生相关的三个预测因素:FLRV <601 cm3,%FLRV和肝硬化。在术后第1周和第5周,再生程度高的患者的肝功能指标明显好于再生程度低的患者,但这些差异在POW 9时消失了。

 

综上所述,该研究结果表明,FLRV,%FLRV和肝硬化严重影响肝切除术后肝再生的程度。低于42.7%的%FLRV值与肝切除术后肝衰竭的更大风险相关。

 

原始出处:

 

Wen-Feng GongJian-Hong Zhong, et al., Evaluation of liver regeneration and post-hepatectomy liver failure after hemihepatectomy in patients with hepatocellular carcinoma. Biosci Rep. 2019 Aug 30; 39(8): BSR20190088. doi: 10.1042/BSR20190088

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    2020-10-12 sunylz
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    2020-04-05 xjy02
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