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Cell Biosci：全反式维甲酸抑制异二聚体骨形态发生蛋白2/7刺激的破骨细胞生成和再吸收活性

2018-09-10 MedSci MedSci原创

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骨再生异二聚体骨形态发生蛋白2/7（BMP2/7）增强破骨细胞生成，而全反式视黄酸（ATRA）则会抑制破骨细胞生成。然而，ATRA对生理和/或BMP2/7诱导的破骨细胞生成的影响仍不清楚。在本研究中，我们旨在探究BMP2/7和ATRA联合治疗对破骨细胞生成和再吸收活性的影响。 在鼠前破骨细胞系RAW264.7或小鼠骨髓衍生的巨噬细胞（BMM）培养物中加入全反式视黄酸（1μM）±BMP2/7（

骨再生异二聚体骨形态发生蛋白2/7（BMP2/7）增强破骨细胞生成，而全反式视黄酸（ATRA）则会抑制破骨细胞生成。然而，ATRA对生理和/或BMP2/7诱导的破骨细胞生成的影响仍不清楚。在本研究中，我们旨在探究BMP2/7和ATRA联合治疗对破骨细胞生成和再吸收活性的影响。

在鼠前破骨细胞系RAW264.7或小鼠骨髓衍生的巨噬细胞（BMM）培养物中加入全反式视黄酸（1μM）±BMP2/7（5或50ng / ml）。分析破骨细胞标志物基因表达，破骨细胞生成和再吸收活性。

结果显示，BMP2/7强有力地增强破骨细胞相关基因的表达，破骨细胞的生成和再吸收活性。有趣的是，不论是否存在BMP2/7，ATRA都可完全抑制破骨细胞的形成。视黄酸受体（RAR）的泛拮抗剂和RARα、β或γ的拮抗剂未能逆转ATRA对破骨细胞生成的抑制作用。ATRA科强烈抑制Rank和Nfatc1的表达。全反式视黄酸可能通过RANKL-RANK通路抑制BMP2/7诱导的破骨细胞生成和再吸收活性。

研究认为，ATRA和BMP2/7的联合使用是治疗过度活跃的破骨细胞诱导的骨丢失的新方法，例如炎症诱导的严重骨质疏松症和由癌转移至骨引起的骨丧失。

原始出处：

Wenjuan Bi, Yi Liu, et al., All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci. 2018; 8: 48.

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    2019-07-19 zhouqu_8

    #酸抑制#

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    2019-02-20 hxj0117

    #二聚体#

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    2019-05-19 sunylz

    #Bio#

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href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 23 15:59:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309991, encodeId=a7fb1309991f6, content=<a href='/topic/show?id=2830e349460' target=_blank style='color:#2F92EE;'>#破骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73494, encryptionId=2830e349460, topicName=破骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207117636891, createdName=drj2009, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2019-08-08 ms1467340776200723

    #骨形态发生蛋白#

    0

  5. 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href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 23 15:59:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309991, encodeId=a7fb1309991f6, content=<a href='/topic/show?id=2830e349460' target=_blank style='color:#2F92EE;'>#破骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73494, encryptionId=2830e349460, topicName=破骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207117636891, createdName=drj2009, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-12-29 维他命

    #CEL#

    0

  6. 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href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 23 15:59:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309991, encodeId=a7fb1309991f6, content=<a href='/topic/show?id=2830e349460' target=_blank style='color:#2F92EE;'>#破骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73494, encryptionId=2830e349460, topicName=破骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207117636891, createdName=drj2009, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2019-05-23 zhaozhouchifen

    #Cell#

    0

  7. 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href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 23 15:59:00 CST 2019, time=2019-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309991, encodeId=a7fb1309991f6, content=<a href='/topic/show?id=2830e349460' target=_blank style='color:#2F92EE;'>#破骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73494, encryptionId=2830e349460, topicName=破骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207117636891, createdName=drj2009, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-12 caobinglei8079

    #破骨细胞#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, 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    2018-09-12 jj000004

    #骨细胞#

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495074, encodeId=7f4214950e4f9, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588946, encodeId=1af6158894665, content=<a href='/topic/show?id=c4512931961' target=_blank style='color:#2F92EE;'>#全反式维甲酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29319, encryptionId=c4512931961, topicName=全反式维甲酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=207117636891, createdName=drj2009, createdTime=Wed Sep 12 07:59:00 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-12 drj2009

    #全反式维甲酸#

    0