Stroke:先兆子痫妇女妊娠相关卒中的危险因素分析!

2017-05-26 xing.T MedSci原创

由此可见,感染、慢性高血压、凝血病和潜在的血栓前状况增加了先兆子痫妇女的PAS风险。这些妇女可能需要更密切的监测。

先兆子痫影响3%至8%的妊娠妇女,并且增加了妊娠相关卒中(PAS)的发生风险。然而由于有限的数据,研究人员无法得知哪些先兆子痫妇女患PAS的风险最高。近日,卒中领域权威杂志Stroke上针对这一问题发表了一篇研究文章。

研究人员使用2003年至2012年期间纽约州卫生厅住院数据库的计费数据,研究人员将先兆子痫和PAS的孕妇根据年龄和种族/民族按1:3的比例匹配了先兆子痫对照者。预先定义的PAS危险因素包括妊娠并发症、入院时感染血管危险因素、血栓前状态和凝血病。研究人员构建了多变量条件Logistic 回归模型,以计算PAS独立危险因素的比值比(Ors)和95%可信区间(95%CIs)。

在研究期间年龄为12-55岁的不管任何原因入住纽约州立医院的妇女(n=3373114)中,88857例女性发生先兆子痫,其中197例(0.2%)有PAS。在多变量分析中,先兆子痫和卒中的妇女比对照者更有可能发生严重先兆子痫或子痫(OR为7.2; 95%CI为4.6-11.3)、入院时存在感染(OR为3.0; 95%CI为1.6-5.8)、血栓前状态(OR为3.5; 95%CI为1.3-9.2)、凝血病(OR为3.1; 95%CI为1.3-7.1)或慢性高血压(OR为3.2; 95%CI为1.8-5.5)。根据先兆子痫严重程度进行匹配和分层的额外分析证实了这些结果。

由此可见,感染、慢性高血压、凝血病和潜在的血栓前状况增加了先兆子痫妇女的PAS风险。这些妇女可能需要更密切的监测。

原始出处:

Eliza C. Miller, et al. Risk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia.Stroke. 2017.https://doi.org/10.1161/STROKEAHA.117.017374

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2017-05-29 大爰

    学习并分享!!

    0

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    2017-05-28 flysky120

    学习一下知识了

    0

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    2017-05-28 meiliwuxian

    学习一下

    0

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    2017-05-27 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

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    2017-05-27 Julie W

    如果可以公开源数据就好了

    0

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    2017-05-27 huaning

    学习了,感谢分享!

    0

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    2017-05-27 执着追梦

    学习,感谢分享

    0

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    2017-05-27 thlabcde

    好东西学习了!

    0

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    2017-05-27 杨利洪

    学习了,提高了

    0

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    2017-05-26 tanxingdoctor

    学习啦谢谢分享

    0

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