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Neurology：无症状老年人APOE非依赖性阿尔茨海默病多基因风险评分与脑淀粉样蛋白沉积的关系

2022-07-02 Naomi MedSci原创

阿尔茨海默症淀粉样沉积
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脑淀粉样沉积是阿尔茨海默病(AD)的主要危险因素。依赖于AD遗传风险因素(不包括APOE)的PRSS可以改善脑淀粉样蛋白的风险预测，允许对认知正常的AD风险个体进行分层，而不依赖于他们的APOE状态。

脑淀粉样沉积是阿尔茨海默病(AD)的主要危险因素，目前通过测量脑脊液或血浆淀粉样肽水平或正电子发射断层成像来评估。在任何堆积发生之前评估与淀粉样蛋白相关的遗传风险将允许对患AD风险较高的人进行更早的干预。之前将淀粉样蛋白负荷与遗传风险联系起来的研究几乎完全依赖于APOE，这是AD的一个主要遗传风险因素。近日，一项发表在Neurology上的研究试图探究多基因风险评分(PRS)是否与认知正常的老年成年人的脑淀粉样蛋白负荷有关，该多基因风险评分包含与AD相关的常见变异的优化列表并排除APOE。

研究共纳入了291名老年无症状参与者，他们来自阿尔茨海默病预测因素(洞察力扩展)队列研究，他们接受了淀粉样蛋白成像，其中包括83名淀粉样阳性(+)参与者。研究使用了由33个AD风险变量组成的阿尔茨海默氏症(A)PR，其中不包括APOE，并选择了17个与淀粉样蛋白阳性相关性最强的变量来定义优化的(OA)PR。阿尔茨海默病神经成像倡议(ADNI)研究的参与者[228名参与者，90个淀粉样蛋白(+)]作为验证队列进行了测试。最后，来自欧洲阿尔茨海默病倡议(EADI)的2300名AD患者和6994名对照进行了评估。

  • 在有或没有APOE基因校正的SAINT或ADNI队列中，A-PR与淀粉样蛋白负荷没有显著相关性。
  • 然而，独立于APOE调整，OA-PR与淀粉样蛋白状态显著相关(Insight OR：5.26[1.7116.88]；ADNI OR：3.38[1.02-11.63])。
  • 有趣的是，OA-PR准确地区分了淀粉样蛋白(+)和(-)载脂蛋白ε4携带者(Insight OR：181.6[7.53-10,674.6]；ADNI OR：44.94[3.031,277])。
  • 在EADI队列中，A-prs和OA-prs与疾病状态显著相关(OR分别为1.68[1.53-1.85]和2.06[1.73-2.45])。
  • 在与Aβ代谢和沉积相关的本体中，分配给OA-PrS变体的基因被丰富。

依赖于AD遗传风险因素(不包括APOE)的PRSS可以改善脑淀粉样蛋白的风险预测，允许对认知正常的AD风险个体进行分层，而不依赖于他们的APOE状态。

文献来源：Lekoubou A, Ba DM, Nguyen C, et al. Poststroke Seizures and the Risk of Dementia Among Young Stroke Survivors [published online ahead of print, 2022 May 18]. Neurology. 2022;10.1212/WNL.0000000000200736. doi:10.1212/WNL.0000000000200736

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    2023-02-11 zsyan

    #脑淀粉样#

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    2022-11-17 12498da4m32(暂无昵称)

    #阿尔茨海#

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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2022-10-04 wangyang7958

    #脑淀粉样蛋白#

    0

  4. 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createdName=12498da4m32(暂无昵称), createdTime=Thu Nov 17 10:24:16 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046720, encodeId=f3412046e20d5, content=<a href='/topic/show?id=f31284915a6' target=_blank style='color:#2F92EE;'>#脑淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84915, encryptionId=f31284915a6, topicName=脑淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Oct 04 00:24:16 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817199, encodeId=62c7181e19922, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-02-01 ms1948154235210413

    #阿尔茨#

    0

  5. 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createdName=12498da4m32(暂无昵称), createdTime=Thu Nov 17 10:24:16 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046720, encodeId=f3412046e20d5, content=<a href='/topic/show?id=f31284915a6' target=_blank style='color:#2F92EE;'>#脑淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84915, encryptionId=f31284915a6, topicName=脑淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Oct 04 00:24:16 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817199, encodeId=62c7181e19922, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-04-13 yinhl1978

    #Neurol#

    0

  6. 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createdName=12498da4m32(暂无昵称), createdTime=Thu Nov 17 10:24:16 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046720, encodeId=f3412046e20d5, content=<a href='/topic/show?id=f31284915a6' target=_blank style='color:#2F92EE;'>#脑淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84915, encryptionId=f31284915a6, topicName=脑淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Oct 04 00:24:16 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817199, encodeId=62c7181e19922, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-03-22 qjddjq

    #多基因风险#

    0

  7. 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createdName=12498da4m32(暂无昵称), createdTime=Thu Nov 17 10:24:16 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046720, encodeId=f3412046e20d5, content=<a href='/topic/show?id=f31284915a6' target=_blank style='color:#2F92EE;'>#脑淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84915, encryptionId=f31284915a6, topicName=脑淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Oct 04 00:24:16 CST 2022, time=2022-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817199, encodeId=62c7181e19922, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-01-14 hmwwww

    #基因风险#

    0

  8. 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encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-02-21 syscxl

    #多基因#

    0

  9. 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encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Feb 01 08:24:16 CST 2023, time=2023-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001851, encodeId=960320018511d, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Apr 13 06:24:16 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949782, encodeId=95881949e82c5, content=<a href='/topic/show?id=b1ec431e5ab' target=_blank style='color:#2F92EE;'>#多基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43175, encryptionId=b1ec431e5ab, topicName=多基因风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Wed Mar 22 14:24:16 CST 2023, time=2023-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704522, encodeId=b4bf1e0452276, content=<a href='/topic/show?id=1f5b41931ce' target=_blank style='color:#2F92EE;'>#基因风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41931, encryptionId=1f5b41931ce, topicName=基因风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb0530750602, createdName=hmwwww, createdTime=Sat Jan 14 09:24:16 CST 2023, time=2023-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754474, encodeId=a1e91e54474be, content=<a href='/topic/show?id=44e2431e1c6' target=_blank style='color:#2F92EE;'>#多基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43171, encryptionId=44e2431e1c6, topicName=多基因)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b34b36693912, createdName=syscxl, createdTime=Tue Feb 21 07:24:16 CST 2023, time=2023-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632095, encodeId=965d1632095a1, content=<a href='/topic/show?id=5138431e665' target=_blank style='color:#2F92EE;'>#多基因风险评分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43176, encryptionId=5138431e665, topicName=多基因风险评分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a1a21855288, createdName=lq0308, createdTime=Mon Feb 27 16:24:16 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442910, encodeId=5cc714429106a, content=<a href='/topic/show?id=e112659308a' target=_blank style='color:#2F92EE;'>#淀粉样蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65930, encryptionId=e112659308a, topicName=淀粉样蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1774999170, createdName=ms7405317358118777, createdTime=Sat Jul 02 13:24:16 CST 2022, time=2022-07-02, status=1, ipAttribution=)]
    2023-02-27 lq0308

    #多基因风险评分#

    0

  10. 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    2022-07-02 ms7405317358118777

    #淀粉样蛋白#

    0

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