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Mol Med Rep：SNHG12上调可促进肝细胞增殖和肝再生

2020-03-18 MedSci原创 MedSci原创

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在部分肝切除术（PH）之后，开始了肝再生的复杂过程，其中包括同步诱导肝细胞增殖。肝细胞增殖可以通过多种刺激来调节，包括长的非编码RNA（lncRNA）和Wnt /β-catenin信号传导，

在部分肝切除术（PH）之后，开始了肝再生的复杂过程，其中包括同步诱导肝细胞增殖。肝细胞增殖可以通过多种刺激来调节，包括长的非编码RNA（lncRNA）和Wnt /β-catenin信号传导，尽管lncRNA / Wnt在肝脏再生中的潜在机制尚不清楚。在本研究中，我们鉴定了与肝脏再生相关的功能性lncRNA，并在体内和体外描述了其功能。

 

2/3 PH后lncRNA小核仁RNA宿主基因12（SNHG12）的表达在各个时间点上调。在不同浓度的肝细胞生长因子（HGF）处理的正常肝细胞系中，SNHG12的表达也增加了。从功能上讲，SNHG12在体外和体内均能增强肝细胞的增殖，并且过表达SNHG12的小鼠的肝脏/体重比显著高于对照小鼠。SNHG12的过表达促进了肝细胞中Wnt /β-catenin信号的激活。此外，对Wnt /β-catenin信号的特异性抑制明显减弱了SNHG12诱导的肝细胞增殖和受影响的肝脏/体重比。

 

总体而言，本研究的结果表明SNHG12通过激活Wnt /β-catenin信号传导促进肝脏再生。因此，调节SNHG12/Wnt轴的药物可能对PH后的肝脏再生有益。

 

原始出处：

 

Yan Zhu, Zhiquan Qiu, et al., Partial hepatectomy-induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration. Mol Med Rep. 2020 Mar; 21(3): 1089–1096. doi: 10.3892/mmr.2019.10904

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    2020-09-03 xjy02

    #肝细胞#

    0

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    2020-03-20 晓辰

    #细胞增殖#

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    2020-03-20 ms3994565386320060

    #Med#

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