J Dent Res:牙周治疗可降低伴有糖尿病前期患者的HbA1c

2019-03-24 不详 网络

有关牙周治疗是否能改善糖尿病前期和牙周病患者血红蛋白A1c(HbA1c)的证据有限,尚不清楚代谢状态的改善是否持续> 3个月。一项多中心随机对照试验“抗生素和牙周炎”(抗生素和牙周炎)的前瞻性,分层,双盲研究的探索性事后分析中,我们评估了有或没有辅助全身性抗生素治疗的非手术牙周治疗在27.5个月的时间内是否会影响正常HbA1c(≤5.7%,n = 218)、前驱糖尿病(5.7%<HbA

有关牙周治疗是否能改善糖尿病前期和牙周病患者血红蛋白A1c(HbA1c)的证据有限,尚不清楚代谢状态的改善是否持续> 3个月。

一项多中心随机对照试验“抗生素和牙周炎”(抗生素和牙周炎)的前瞻性,分层,双盲研究的探索性事后分析中,我们评估了有或没有辅助全身性抗生素治疗的非手术牙周治疗在27.5个月的时间内是否会影响正常HbA1c(≤5.7%,n = 218)、前驱糖尿病(5.7%糖尿病(HbA1c≥6.5%,n = 8)的牙周炎患者的HbA1c和高敏C-反应蛋白(hsCRP)的水平)。

结果显示,非手术牙周治疗使两组的平均口袋探测深度减少> 1 mm。在正常的HbA1c组中,在观察期间HbA1c值保持不变,为5.0%(95%CI,4.9%~6.1%)。在患有前驱糖尿病的牙周炎患者中,HbA1c在15.5月时从5.9%(95%CI,5.9%~6.0%)降至5.4%(95%CI,5.3%~5.5%),27.5个月后增加至5.6%(95%CI,5.4%~5.7%)。在27.5个月时,46%的前驱糖尿病的牙周炎患者具有正常的HbA1c水平,而47.9%保持不变且6.3%进展为糖尿病。正常HbA1c和前驱糖尿病组的中位hsCRP值分别从1.2和1.4 mg/L降至0.7和0.7 mg/L。

总之,该研究结果表明,非牙周牙周治疗可以改善伴有前驱糖尿病牙周炎患者的血糖值。

原始出处:

Kocher T, Holtfreter B, et al., Effect of Periodontal Treatment on HbA1c among Patients with Prediabetes. J Dent Res. 2019 Feb;98(2):171-179. doi: 10.1177/0022034518804185. Epub 2018 Oct 16.

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