STM:尼帕病毒和亨德拉病毒治疗性疫苗问世

2012-08-09 任海军 新华网

美国研究人员8月8日在美国《科学—转化医学》杂志上报告说,他们已开发出了针对尼帕病毒和亨德拉病毒的高效疫苗。   尼帕病毒及与其关系紧密的亨德拉病毒均为美国国家卫生研究院研究的罕见病毒,它们能攻击人和动物的肺部和大脑,死亡率分别高达75%和60%,而尼帕病毒还可以人际间传播。   研究人员以亨德拉病毒的表面蛋白——G蛋白为基础,研制出新疫苗,这种疫苗可以激发宿主的免疫反

美国研究人员8月8日在美国《科学—转化医学》杂志上报告说,他们已开发出了针对尼帕病毒和亨德拉病毒的高效疫苗。
 
尼帕病毒及与其关系紧密的亨德拉病毒均为美国国家卫生研究院研究的罕见病毒,它们能攻击人和动物的肺部和大脑,死亡率分别高达75%和60%,而尼帕病毒还可以人际间传播。
 
研究人员以亨德拉病毒的表面蛋白——G蛋白为基础,研制出新疫苗,这种疫苗可以激发宿主的免疫反应。结果显示,这种疫苗不仅对感染了亨德拉病毒的雪貂和马有效,还能保护感染尼帕病毒的猫。
 
研究人员进一步对9只非洲绿猴展开了实验,它们被分为3组,每组接种不同剂量的疫苗。42天后研究人员让它们感染了尼帕病毒,结果这些绿猴都得以幸存。
 
研究论文作者、美国军队卫生服务大学教授克里斯托弗·布罗德表示,这项发现提供了人类感染尼帕病毒或亨德拉病毒的潜在疗法。
 
研究人员计划下一步搜集更多数据,以便获得美国食品和药物管理局批准,将疫苗应用到人体上。
 
链接:Katharine N. Bossart1,2,*, Barry Rockx3,4,*, Friederike Feldmann5, Doug Brining6, Dana Scott6, Rachel LaCasse6, Joan B. Geisbert7,8, Yan-Ru Feng9, Yee-Peng Chan9, Andrew C. Hickey1,2, Christopher C. Broder9,†, Heinz Feldmann3,10 and Thomas W. Geisbert7,8.A Hendra Virus G Glycoprotein Subunit Vaccine Protects African Green Monkeys from Nipah Virus Challenge.Sci Transl Med

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    2012-09-27 gdsun
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