Breast Cancer Res Treat:乳腺癌患者内乳淋巴结治疗的盲区

2015-05-03 范伟译 MedSci原创

目的:乳腺癌患者常规临床治疗不涉及内乳淋巴结,需要乳腺切除后的放射治疗是有争议的。本研究的目的是测量内乳淋巴结的辐射剂量,不包括接受乳房切除术放射治疗后乳腺癌妇女计划的目标体积。方法:这个回顾性方案利用基于CT三维适形治疗计划。分析50个患者:包括25左乳腺癌和25右乳腺癌患者。三维适形治疗计划胸壁切线区域和匹配的锁骨上区。所有计划规定25%胸壁给予总剂量50 Gy ,23%锁

目的:乳腺癌患者常规临床治疗不涉及内乳淋巴结,需要乳腺切除后的放射治疗是有争议的。本研究的目的是测量内乳淋巴结的辐射剂量,不包括接受乳房切除术放射治疗后乳腺癌妇女计划的目标体积。

方法:这个回顾性方案利用基于CT三维适形治疗计划。分析50个患者:包括25左乳腺癌和25右乳腺癌患者。三维适形治疗计划胸壁切线区域和匹配的锁骨上区。所有计划规定25%胸壁给予总剂量50 Gy ,23%锁骨上区域给予总剂量46 Gy 。内乳淋巴链不包括在目标体积内。

结果:乳房内部血管在放射治疗后肿瘤组是波状外形的,图谱显示有7毫米计划的目标体积的扩展,利用原始CT仿真图像。内乳淋巴结是波状外形的,在第一个3和5的肋间区域进行比较。内乳淋巴结体积百分比计划的目标体积接受95%处方剂量(47.5 Gy)有7毫米扩张,所有患者前5肋间区域接受25.2%(范围0.04 - 97.6%,标准偏差(SD)23.5)。所有患者的平均内乳淋巴结剂量24.98 Gy(范围3.54 -55.93 Gy,SD 16)。

结论:本研究的结果表明,在乳腺癌患者乳房切除术予以标准的三维适形放射治疗胸壁后,给予内乳淋巴结偶然的剂量治疗并未达到临床上显著的治疗水平。如果微观参与的风险因素存在,内乳淋巴结必须明确包括的目标体积,这为了确保更准确的接受治疗。

原始出处:

Arora D1, Frakes J, Scott J, Opp D, Johnson C, Song J,Harris E.Incidental radiation to uninvolved internal mammary lymph nodes in breast cancer.Breast Cancer Res Treat. 2015 May 1.

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    2015-08-17 ms3153534357578991

    #TREAT#

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    2016-02-02 ms24272190615788285182

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    2015-05-05 sodoo

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    2015-05-05 zhaojie88

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