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CCLM：通过线性免疫分析慢性炎性脱髓鞘性多发性神经病（CIDP）患者的抗神经节苷脂抗体？

2018-06-01 MedSci MedSci原创

慢性炎性脱髓鞘性多发性神经病
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与急性免疫介导的神经病变(IN)不同，抗神经节苷自身抗体(aGAAb)检测目前只被推荐用于少数慢性神经病变。因此，我们使用多路半定量细胞系免疫分析(LIA)在慢性炎性脱髓鞘性多神经病变(CIDP)及其临床变异中寻找aGAAb。 研究人员通过LIA Anti-GAAb 11神经节甘脂和硫苷脂(SF)调查61个 (27个典型CIDP 12 distal-acquired脱髓鞘多神经病,6 mul

与急性免疫介导的神经病变(IN)不同，抗神经节苷自身抗体(aGAAb)检测目前只被推荐用于少数慢性神经病变。因此，我们使用多路半定量细胞系免疫分析(LIA)在慢性炎性脱髓鞘性多神经病变(CIDP)及其临床变异中寻找aGAAb。

研究人员通过LIA Anti-GAAb 11神经节甘脂和硫苷脂(SF)调查61个 (27个典型CIDP 12 distal-acquired脱髓鞘多神经病,6 multifocal-acquired脱髓鞘感觉/运动多神经病,10感官CIDP 1焦CIDP和5 multifocal-motoric神经病变),以及40其他神经肌肉疾病(15非免疫多神经病,25重症肌无力)，29个多发性硬化症(MS) 患者和54名健康对照 (HC)。

结果显示，与IgG相比，在IN中17/61(27.9%)中发现了至少一种神经节苷/SF的抗gaab IgM阳性，而在OND为 2/40(5%)、MS为 2/29 (6.9%)和HC为 4/54(7.4%)。在统计学意义上，抗磺胺药(aSF) IgM的发生率高于OND (p=0.008)。此外，aGM1 IgM比OND和HC更普遍(p=0.009)， GD1b更普遍(p<0.04)。与多灶性运动神经病(MMN)相比，CIDP的aGM1 IgM患病率较低(12% vs 60%， p=0.027)。aSF、aGM1、aGM2 IgM患者较aGAAb阴性患者更年轻(p<0.05)。aSF IgM阳性患者CIDP和MMN表型更为常见(p<0.05)。

aGAAb LIA显示至少一个aGAAb IgM在CIDP/MMN患者中升高。抗sf、aGM1和aGM2 IgM与年轻年龄相关，抗sf与表型相关。

原始出处：

Juliane Klehmet, Analysis of anti-ganglioside antibodies by a line immunoassay in patients with chronic-inflammatory demyelinating polyneuropathies (CIDP)

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


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    2019-03-06 xlxchina

    #CID#

    0

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    2018-09-13 xiaogang329

    #髓鞘#

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2019-04-07 jiangfeng5067

    #免疫分析#

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-09-23 jml2009

    #多发性#

    0

  5. 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encodeId=029e320834f9, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 02 12:44:17 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320569, encodeId=a4313205692a, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:04:55 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-08-29 ms3892185887221420

    #多发性神经病#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1991597, encodeId=7c9b199159e65, content=<a href='/topic/show?id=f88a4e047f' target=_blank style='color:#2F92EE;'>#CID#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4704, encryptionId=f88a4e047f, topicName=CID)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Mar 06 16:04:00 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755063, encodeId=56141e5506364, content=<a href='/topic/show?id=d1011021391e' target=_blank style='color:#2F92EE;'>#髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102139, encryptionId=d1011021391e, topicName=髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f28436833652, 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encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Sep 23 15:04:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709209, encodeId=f8051e09209ff, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Wed Aug 29 05:04:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491310, encodeId=036b1491310b4, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Sun Jun 03 05:04:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516403, encodeId=226a1516403b5, content=<a href='/topic/show?id=8160852e55c' target=_blank style='color:#2F92EE;'>#脱髓鞘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85275, encryptionId=8160852e55c, topicName=脱髓鞘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3ba10959947, createdName=1696533704_45270457, createdTime=Sun Jun 03 05:04:00 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320834, encodeId=029e320834f9, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 02 12:44:17 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320569, encodeId=a4313205692a, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:04:55 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-03 axin012

    #神经病#

    0

  7. 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encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sun Sep 23 15:04:00 CST 2018, time=2018-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709209, encodeId=f8051e09209ff, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Wed Aug 29 05:04:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491310, encodeId=036b1491310b4, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, 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encodeId=029e320834f9, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 02 12:44:17 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320569, encodeId=a4313205692a, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:04:55 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-03 1696533704_45270457

    #脱髓鞘#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-02 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  9. 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encodeId=029e320834f9, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jun 02 12:44:17 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320569, encodeId=a4313205692a, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:04:55 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 139****5926

    好好文章学习了

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320558, encodeId=b87032055864, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Jun 01 14:15:49 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 大爰

    学习了谢谢分享!!

    0

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