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PNAS：新化合物能抗击耐药菌

2011-10-04 MedSci原创 MedSci原创

耐药菌

　　耶鲁大学科学家使用人类免疫系统中的物质开发出了一种能中和或杀灭多种耐药菌和其他危险菌的化合物，这为感染性疾病新的治疗方法带来了希望。相关研究于9月26日发表于《美国国家科学院院刊》（PNAS）。 　　诺贝尔奖得主、该研究高级研究作者、化学教授Sidney Altman说，“在当前药物中使用的浓度下该化合物是有效的，并有望用于抗击感染性疾病及耐药性生物。”1989年，Altman和Thomas

　　耶鲁大学科学家使用人类免疫系统中的物质开发出了一种能中和或杀灭多种耐药菌和其他危险菌的化合物，这为感染性疾病新的治疗方法带来了希望。相关研究于9月26日发表于《美国国家科学院院刊》（PNAS）。

　　诺贝尔奖得主、该研究高级研究作者、化学教授Sidney Altman说，“在当前药物中使用的浓度下该化合物是有效的，并有望用于抗击感染性疾病及耐药性生物。”1989年，Altman和Thomas R. Cech一道发现RNA的催化性能，并因此荣获了诺贝尔化学奖。

　　新方法使用一种RNA的片断来抑制造成发病机制的基因表达，该RNA可”编码”以上基因。最终产物在暴露于细胞内的一种酶后，关闭了使细菌存活的基因表达。

　　通过致力于细胞培养工作，耶鲁大学科学家发现他们可以使用1种新化合物促进这种RNA在多种细菌细胞中传递，这种新化合物以人类T细胞中的一种肽为基础。它不仅使菌株对当前药物更敏感，而且还能通过靶向于关乎细胞生存的基因杀灭细菌。科学家估计，此方法“靶定”细菌的有效性较现有化合物高出 10～100倍。

　　“我们认为该化合物将在老鼠中有效并可以从老鼠转至人类，”Altman说。

        新闻链接：New Compound Combats Drug-Resistant Bacteria, Nobel Laureate Shows

评论区 (3)
#插入话题
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    2011-11-03 drwjr

    #PNAS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1855226, encodeId=185a185522601, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Thu Nov 03 02:12:00 CST 2011, time=2011-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906246, encodeId=763f190624657, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Dec 03 23:12:00 CST 2011, time=2011-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418645, encodeId=9bb51418645a1, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Oct 06 13:12:00 CST 2011, time=2011-10-06, status=1, ipAttribution=)]
    2011-12-03 wangyang7958

    #化合物#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1855226, encodeId=185a185522601, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Thu Nov 03 02:12:00 CST 2011, time=2011-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906246, encodeId=763f190624657, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sat Dec 03 23:12:00 CST 2011, time=2011-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418645, encodeId=9bb51418645a1, content=<a href='/topic/show?id=b07e8041efb' target=_blank style='color:#2F92EE;'>#耐药菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80417, encryptionId=b07e8041efb, topicName=耐药菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10723392161, createdName=xiaoshitou, createdTime=Thu Oct 06 13:12:00 CST 2011, time=2011-10-06, status=1, ipAttribution=)]
    2011-10-06 xiaoshitou

    #耐药菌#

    0