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J Periodontal Res：激光处理为何会有益于种植体周围炎的治疗？

2018-02-08 MedSci MedSci原创

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种植体周围炎和牙周治疗方面，高功率激光器越来越适用于外科清创和抗菌治疗。有害病灶的清除自然会直接促进组织愈合。然而，也有关于常规高功率激光手术愈合良好的报道。但是目前有待于阐明这些影响的确切机制。本研究旨在探究这些低剂量激光对口腔人类上皮细胞和成纤维细胞的影响，特别是对人类β-防御素2（HBD-2或DEFB4A）的作用。 使用低剂量的近红外激光（810nm二极管）进行激光治疗。使用正常人口腔角质形

种植体周围炎和牙周治疗方面，高功率激光器越来越适用于外科清创和抗菌治疗。有害病灶的清除自然会直接促进组织愈合。然而，也有关于常规高功率激光手术愈合良好的报道。但是目前有待于阐明这些影响的确切机制。本研究旨在探究这些低剂量激光对口腔人类上皮细胞和成纤维细胞的影响，特别是对人类β-防御素2（HBD-2或DEFB4A）的作用。

使用低剂量的近红外激光（810nm二极管）进行激光治疗。使用正常人口腔角质形成细胞和成纤维细胞细胞，并使用实时聚合酶链式反应、蛋白质印迹和免疫染色评估HBD-2 mRNA和蛋白质表达。利用通路特异性小分子抑制剂探究转化生长因子（TGF）-β1信号在此过程中的作用。

结果显示，与角质形成细胞系相比，激光治疗强烈诱导口腔成纤维细胞系中HBD-2的表达。低剂量激光治疗导致介导HBD-2表达的TGF-β1通路的活化。 TGF-β1信号传导的两个臂，Smad和非Smad都参与激光介导的HBD-2的表达。

综上所述，该研究结果表明，激光活化的TGF-β1信号传导和HBD-2的诱导表达，两者均能够促进邻近高功率手术激光应用的组织中的愈合。此外，使用低剂量激光疗法本身可以为牙周或种植体周围疾病的有效临床管理提供额外的治疗益处。

原始出处：

Tang E, Khan I, et al., Laser-activated transforming growth factor-β1 induces human β-defensin 2: implications for laser therapies for periodontitis and peri-implantitis. J Periodontal Res. 2017 Jun;52(3):360-367. doi: 10.1111/jre.12399. Epub 2016 Jul 11.

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    2018-10-12 huangdf

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    2019-01-08 feather89

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    2018-02-10 oliver169

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